Chronic Lymphocytic Leukemia
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A graph representing the sequence of genomic alterations in chronic lymphocytic leukemia (CLL). Each node represents a mutation, with arrows indicating temporal relationships between them. The size of the nodes indicates the number of patients in the study who exhibited the alteration, while the thickness of the lines shows how often the temporal relationships between nodes were seen. The method the researchers use enabled them to identify multiple, distinct evolutionary patterns in CLL.
“Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia.”
AUTHORS: Jiguang Wang*, Hossein Khiabanian*, Davide Rossi*, et al.
LINK TO PUBLICATION:
eLife 2014 Dec 11; doi: 10.7554/eLife.02869.
* These authors have contributed equally to this work.