Selected
Publications
Our main scientific interests lie in modeling and understanding the dynamics of biological
systems through the lens of genomics. Our work focuses on three distinct topics:
Cancer, Infectious Diseases, and Electronic Health Records.
This page contains links to Selected Publications. We also have a full Publications Archive.
“Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma.”
AUTHORS: Enrico Tiacci, Erik Ladewig, Gianluca Schiavoni, Alex Penson, Elisabetta Fortini, Valentina Pettirossi, Yuchun Wang, Ariele Rosseto, Alessandra Venanzi, Sofija Vlasevska, Roberta Pacini, Simonetta Piattoni, Alessia Tabarrini, Alessandra Pucciarini, Barbara Bigerna, Alessia Santi, Alessandro M Gianni, Simonetta Viviani, Antonello Cabras, Stefano Ascani, Barbara Crescenzi, Cristina Mecucci, Laura Pasqualucci, Raul Rabadan, Brunangelo Falini.
Blood [12 Apr 2018, 131(22):2454-2465]. doi:10.1182/blood-2017-11-814913.
“Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma.”
AUTHORS: Luis Arnes, Zhaoqi Liu, Jiguang Wang, Hans Carlo Maurer, Irina Sagalovskiy, Marta Sanchez-Martin, Nikhil Bommakanti, Diana C Garofalo, Dina A Balderes, Lori Sussel, Kenneth P Olive, Raul Rabadan.
Gut Published Online First: 10 February 2018. doi: 10.1136/gutjnl-2017-314353.
“Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia.”
AUTHORS: Gannie Tzoneva, Chelsea L Dieck, Koichi Oshima, Alberto Ambesi-Impiombato, Marta Sánchez-Martín, Chioma J Madubata, Hossein Khiabanian, Jiangyan Yu, Esme Waanders, Ilaria Iacobucci, Maria Luisa Sulis, Motohiro Kato, Katsuyoshi Koh, Maddalena Paganin, Giuseppe Basso, Julie M Gastier-Foster, Mignon L Loh, Renate Kirschner-Schwabe, Charles G Mullighan, Raul Rabadan, Adolfo A Ferrando.
Nature volume 553, pages 511–514 (25 January 2018) doi:10.1038/nature25186.
“Identification of potentially oncogenic alterations from tumor-only samples reveals Fanconi anemia pathway mutations in bladder carcinomas.”
AUTHORS: Chioma J Madubata, Alireza Roshan-Ghias, Timothy Chu, Samuel Resnick, Junfei Zhao, Luis Arnes, Jiguang Wang & Raul Rabadan.
npj Genomic Medicine. 2017 Oct. doi:10.1038/s41525-017-0032-5.
“Geometry and topology of genomic data.”
AUTHORS: A.J. Blumberg and R. Rabadan.
Chapter 64 in J.E. Goodman, J. O'Rourke, and C.D. Toth, editors.
“Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development.”
AUTHORS: Abbas H Rizvi, Pablo G Camara, Elena K Kandror, Thomas J Roberts, Ira Schieren, Tom Maniatis & Raul Rabadan.
“Spatiotemporal genomic architecture informs precision oncology in glioblastoma.”
AUTHORS: Lee JK*, Wang J*, Sa JK*, Ladewig E*, Lee HO, Lee IH, Kang HJ, Rosenbloom DS, Camara PG, Liu Z, van Nieuwenhuizen P, Jung SW, Choi SW, Kim J, Chen A, Kim KT, Shin S, Seo YJ, Oh JM, Shin YJ, Park CK, Kong DS, Seol HJ, Blumberg A, Lee JI, Iavarone A, Park WY+, Rabadan R+, Nam DH+.
* These authors have contributed equally to this work. +Corresponding authors.
“Evolutionary scalpels for dissecting tumor ecosystems.”
AUTHORS: Daniel I.S. Rosenbloom , Pablo G. Camara, Tim Chu, Raul Rabadan.
BBA-Reviews on Cancer. 2016 December. doi: 10.1016/j.bbcan.2016.11.005.
“Topological Summaries of Tumor Images Improve Prediction of Disease Free Survival in Glioblastoma Multiforme.”
AUTHORS: Lorin Crawford, Anthea Monod, Andrew X. Chen, Sayan Mukherjee, Raúl Rabadán.
“Inference of Ancestral Recombination Graphs through Topological Data Analysis.”
AUTHORS: Pablo G. Cámara, Arnold J. Levine, Raúl Rabadán.
PLOS Computational Biology. 2016 August. doi: 10.1371/journal.pcbi.1005071.
“Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.”
AUTHORS: Koichi Oshima*, Hossein Khiabanian*, Ana C. da Silva-Almeida, Gannie Tzoneva, Francesco Abate, Alberto Ambesi-Impiombato, Marta Sanchez-Martin, Zachary Carpenter, Alex Penson, Arianne Perez-Garcia, Cornelia Eckert, Concepción Nicolas, Milagros Balbin, Maria Luisa Sulis, Motohiro Kato, Katsuyoshi Koh, Maddalena Paganin, Giuseppe Basso, Julie M. Gastier-Foster, Meenakshi Devidas, Mignon L. Loh, Renate Kirschner-Schwabe, Teresa Palomero+, Raul Rabadan+, and Adolfo A. Ferrando+.
* These authors have contributed equally to this work.+Corresponding authors.
“Genomic data analysis in tree spaces.”
AUTHORS: Sakellarios Zairis, Hossein Khiabanian, Andrew J. Blumberg, Raul Rabadan.
“Clonal evolution of glioblastoma under therapy.”
AUTHORS: Jiguang Wang, Emanuela Cazzato, Erik Ladewig, Veronique Frattini, Daniel I S Rosenbloom, Sakellarios Zairis, Francesco Abate, Zhaoqi Liu, Oliver Elliott, Yong-Jae Shin, Jin-Ku Lee, In-Hee Lee, Woong-Yang Park, Marica Eoli, Andrew J Blumberg, Anna Lasorella, Do-Hyun Nam, Gaetano Finocchiaro, Antonio Iavarone, Raul Rabadan.
“Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination.”
AUTHORS: Pablo G. Camara, Daniel I.S. Rosenbloom, Kevin J. Emmett, Arnold J. Levine, Raul Rabadan.
“Reprogramming eukaryotic translation with ligand-responsive synthetic RNA switches.”
AUTHORS: Anzalone AV, Lin AJ, Zairis S, Rabadan R, Cornish VW.